In 1961, it was demonstrated that the enzyme ribonuclease can correctly fold upon oxidation in air from a fully reduced and denatured polypeptide chain. Since then, the principles that govern the oxidative folding of polypeptide chains have been elucidated, and our ability to control this process has advanced significantly.
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Wu, C. Decoupling sequence and structure. Nat Rev Chem 9, 363–364 (2025). https://doi.org/10.1038/s41570-025-00726-2
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DOI: https://doi.org/10.1038/s41570-025-00726-2
