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COLORECTAL CANCER

TMB is linked with prognosis

Nature Reviews Clinical Oncology volume 16, page 336 (2019)Cite this article

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Limited molecular markers are available to guide therapeutic decisions for patients with advanced-stage colorectal cancer (CRC). Now, a comprehensive mutational analysis of CRC samples indicates that several genetic features provide prognostic information in this setting.

This analysis was performed on a subset of tumour specimens from 2,326 patients with newly diagnosed, advanced-stage CRC collected before treatment in the CALGB/SWOG 80405 trial. In this trial, patients received chemotherapy plus bevacizumab and/or cetuximab; no significant difference in overall survival (OS) was reported between arms. Mutational analysis of 11 genes was performed in 843 patients, 827 of which were profiled for microsatellite instability (MSI) status. Tumour mutational burden (TMB) was assessed in samples from 1,300 patients.

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  1. Nature Reviews Clinical Oncology http://www.nature.com/nrclinonc

    Diana Romero

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  1. Diana Romero
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Correspondence to Diana Romero.

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Romero, D. TMB is linked with prognosis. Nat Rev Clin Oncol 16, 336 (2019). https://doi.org/10.1038/s41571-019-0206-4

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