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Male hormonal contraceptive — are we there yet?

Nature Reviews Endocrinology volume 14, pages 685–686 (2018)Cite this article

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A male hormonal contraceptive would be a welcome addition to current family planning efforts. Herein, we summarize efforts to develop such a contraceptive, with a focus on contraceptive efficacy studies and new compounds that might offer advantages in terms of route of administration and longer half-lives compared with older compounds.

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References

  1. World Health Organization Task Force of Methods for the Regulation of Male Fertility. Contraceptive efficacy of testosterone-induced azoospermia and oligozoospermia in normal men. Fertil. Steril. 65, 821–829 (1996).

    Article  Google Scholar 

  2. Gu, Y. Q. et al. A multicenter contraceptive efficacy study of injectable testosterone undeanoate in healthy Chinese men. J. Clin. Endocrinol. Metab. 88, 562–568 (2003).

    Article  CAS  Google Scholar 

  3. Gu, Y. et al. Multicenter contraceptive efficacy trial of injectable testosterone undecanoate in Chinese men. J. Clin. Endocrinol. Metab. 94, 1910–1915 (2009).

    Article  CAS  Google Scholar 

  4. Turner, L. et al. Contraceptive efficacy of a depot progestin and androgen combination in men. J. Clin. Endocrinol. Metab. 88, 4659–4667 (2003).

    Article  CAS  Google Scholar 

  5. Behre, H. M. et al. Efficacy and safety of an injectable combination hormonal contraceptive for men. J. Clin. Endocrinol. Metab. 101, 4779–4788 (2016).

    Article  CAS  Google Scholar 

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Acknowledgements

The authors acknowledge the support of Eunice Kennedy Shriver National Institute of Child Health and Human Development, a division of the NIH through cooperative agreement K24HD082231 (J.K.A.), contract HHSN27520130024I, and the Robert B. McMillen Professorship in Lipid Research at the University of Washington (S.T.P.). The authors thank W.J. Bremner for critical review of the manuscript.

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  1. Center for Research in Reproduction and Contraception, University of Washington, Department of Medicine, Seattle, WA, USA

    Stephanie T. Page & John K. Amory

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  1. Stephanie T. Page
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  2. John K. Amory
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Correspondence to John K. Amory.

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The authors declare no competing interests.

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Page, S.T., Amory, J.K. Male hormonal contraceptive — are we there yet?. Nat Rev Endocrinol 14, 685–686 (2018). https://doi.org/10.1038/s41574-018-0111-4

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