As the global increase in type 2 diabetes mellitus has a steep upward slope, meeting the worldwide demand for insulin is an international challenge. Sanjay Basu and colleagues used microsimulation to create scenarios that can inform the design of health-care strategies and insulin requirements for governments and the national and international organizations responsible for formulating treatment guidelines.
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References
International Diabetes Federation. IDF Diabetes Atlas 8th edn (International Diabetes Federation, 2017).
Utumatwishima, J. N. et al. Reversing the tide - diagnosis and prevention of T2DM in populations of African descent. Nat. Rev. Endocrinol. 14, 45–56 (2018).
Basu, S., Shankar, V. & Yudkin, J. S. Comparative effectiveness and cost-effectiveness of treat-to-target versus benefit-based tailored treatment of type 2 diabetes in low-income and middle-income countries: a modelling analysis. Lancet Diabetes Endocrinol. 4, 922–932 (2016).
UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352, 837–853 (1998).
Al-Rifai, R. H. et al. Association between diabetes mellitus and active tuberculosis: a systematic review and meta-analysis. PLOS ONE 12, e0187967 (2017).
Owens, D. R. Clinical evidence for the earlier initiation of insulin therapy in type 2 diabetes. Diabetes Technol. Ther. 15, 776–785 (2013).
Basu, S. et al. Estimation of global insulin use for type 2 diabetes, 2018-30: a microsimulation analysis. Lancet Diabetes Endocrinol. 7, 25–33 (2018).
Rutter, C. M., Zaslavsky, A. M. & Feuer, E. J. Dynamic microsimulation models for health outcomes: a review. Med. Decis. Making 31, 10–18 (2011).
Salomon, J. A. et al. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. Lancet 380, 2129–2143 (2012).
CantyMedia. The world: life expectancy — Top 100+. geoba.se http://www.geoba.se/population.php?pc=world&type=015&year=2018&st=country&asde=&page=1 (2018).
Acknowledgements
M.F.H-R. and A.E.S. are supported by the intramural programme of the National Institute of Diabetes, Digestive and Kidney Diseases and the NIH. In addition, A.E.S. is supported by the intramural programme of the National Institute of Minority Health and Health Disparities and the NIH.
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Horlyck-Romanovsky, M.F., Sumner, A.E. Treating T2DM by ensuring insulin access is a global challenge. Nat Rev Endocrinol 15, 135–137 (2019). https://doi.org/10.1038/s41574-019-0160-3
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DOI: https://doi.org/10.1038/s41574-019-0160-3
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