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NEUROENDOCRINOLOGY

Mapping neuron functions in the gut–brain axis

Nature Reviews Endocrinology volume 17, page 448 (2021)Cite this article

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Gut-innervating sensory neurons are essential for regulation of satiety and blood levels of glucose after food consumption. However, the precise functions of different populations of these neurons are poorly understood. A recent Cell Metabolism article interrogated the locations and functions of several molecularly defined gut-innervating neuron populations.

The researchers then investigated two populations of vagal afferents, expressing either Glp1r (GLP1R-neurons) or Gpr65 (GPR65-neurons). “These two genetically distinct vagal sensory neuron populations, which selectively innervate the gut, differently control glucose tolerance and hepatic glucose production,” explain authors Diba Borgmann and Elisa Ciglieri.

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  1. Nature Reviews Endocrinology http://www.nature.com/nrendo/

    Olivia Tysoe

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  1. Olivia Tysoe
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Correspondence to Olivia Tysoe.

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Tysoe, O. Mapping neuron functions in the gut–brain axis. Nat Rev Endocrinol 17, 448 (2021). https://doi.org/10.1038/s41574-021-00519-9

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