Table 1 Sex-specific pulmonary ACE2 expression
From: Sex hormones in SARS-CoV-2 susceptibility: key players or confounders?
ACE2 | Species | Sample | Ref. |
|---|---|---|---|
Increased expression in men or male animals | Human | Airway secretory, AT1 and AT2 cells (single-cell meta-analysis) | |
Lung tissue (RNA and protein) | |||
Lung epithelial cells (RNA) | |||
Lung tissue (GTEx data) | |||
Airway epithelial cells (RNA) | |||
Primary isolated airway smooth muscle cells (protein) | |||
Mouse | Lung tissue (RNA and protein) | ||
Increased expression in women | Human | Lung tissue (RNA) | |
No sex difference | Human | Lung tissue (RNA) | |
Bronchial epithelial cells | |||
Lung and associated respiratory tissues (GEO data) | |||
Lung tissue (GTEx data) | |||
Lung tissue (RNA and protein) | |||
Lung tissue (GTEx and TCGA data) | |||
Bronchial brushing and bronchial biopsies (RNA) | |||
Lung tissue (GEO data) | |||
Lung tissue (GTEx data) | |||
Bronchial epithelial cells (GEO data) | |||
Lung tissue from organ donors (RNA) | |||
Lung tissue (GTEx data) | |||
Lung tissue (TCGA data) | |||
Upper respiratory cilia (protein) | |||
Primary lung epithelial cell cultures (RNA) | |||
Lung tissue (GTEx data) | |||
Mouse | Lung tissue (RNA and protein) | ||
Lung tissue (protein) | |||
Lung tissue (RNA) | |||
Rat | Lung tissue (RNA) |
