Table 1 Paediatric-onset pituitary adenomas treated with temozolomide
Sex | Age at diagnosis (years) | Age at temozolomide treatment (years) | Dose and response to temozolomide | Anterior pituitary hormone staining | Ref. |
|---|---|---|---|---|---|
Male | 13 | 16 | 200 mg/m2 per day, 5 days per month; good prolactin and size response | Prolactin | |
Female | 8 | 8 | 200 mg/m2 per day, 5 days per month | Prolactin | Felker et al.257 |
Male | 14 | 18 | 200 mg/m2 per day, 5 days per month, 40% shrinkage after 6 cycles | Growth hormone and prolactin | Lasolle et al.258 |
Male | 4 (AIP positive) | 4 | 180 mg per day, 5 days per month | Growth hormone | Dutta et al.204 |
Female | 9 | 9 | 200 mg/m2 per day, 5 days per month | Hormone negative | Guzel et al.60 |
Female | 13 | 25 | 75–200 mg/m2 per day, 5 days per month, 50% shrinkage after 12 cycles | Adrenocorticotropin | Lasolle et al.258 |
Female | 17 | 27 | 5 mg per day, 5 days per month | Prolactin | Chentli et al.259 |
Male | 18 | 19.75 | 200 mg/m2 per day, 5 days per month, partial biochemical response, poor tumour size response | Prolactin | Arya et al.6 |
