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Reproductive endocrinology

ZMIZ1 supports endometrial oestrogen and progesterone signalling

Nature Reviews Endocrinology (2026)Cite this article

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Endometrial responses to oestrogen and progesterone are important in maintaining reproductive health. Advancing understanding of the pathways involved in these responses could help to improve treatment and preventive measures for health issues such as infertility and endometrial cancer. A recent paper published in The Journal of Clinical Investigation contributes to this understanding by revealing previously unknown roles of the protein ZMIZ1 in the endometrium.

The researchers investigated the relationship between oestrogen receptor-α (ESR1) signalling, which involves binding of ESR1 to specific chromatin regions to regulate transcription, and Zmiz1. They analysed data from chromatin immunoprecipitation followed by sequencing (ChIP-seq) of endometrial biopsy samples taken from mice that had been treated with oestrogen. Their results showed binding of ESR1 to an enhancer site adjacent to Zmiz1. They also found high levels of H3K27 acetylation, a marker of chromatin accessibility, at this site, which suggests that oestrogen signalling substantially increases the activity of this enhancer to promote Zmiz1 transcription.

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References

Original article

  • Hewitt, S. C. et al. Transcriptional coregulator ZMIZ1 modulates estrogen responses that are essential for healthy endometrial function. J. Clin. Invest. 135, e193212 (2025)

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  1. Nature Reviews Endocrinology http://www.nature.com/nrendo/

    Senegal Carty

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  1. Senegal Carty
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Correspondence to Senegal Carty.

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Carty, S. ZMIZ1 supports endometrial oestrogen and progesterone signalling. Nat Rev Endocrinol (2026). https://doi.org/10.1038/s41574-025-01230-9

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  • DOI: https://doi.org/10.1038/s41574-025-01230-9

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