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Improving hepatic ischaemia–reperfusion injury outcomes

Nature Reviews Gastroenterology & Hepatology volume 16, page 583 (2019)Cite this article

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Two new studies have extended our understanding of hepatic ischaemia–reperfusion injury (IRI), demonstrating how antibiotic pretreatment can improve outcomes in liver transplant recipients and finding that the administration of small-molecule inhibitors of cyclophilin D (CypD) can protect against this injury in mice.

Hepatic IRI is a pro-inflammatory response initiated when blood circulation is restored to tissues after a period of ischaemia. Despite being a major cause of early allograft dysfunction (EAD) following liver transplantation, and contributing to the problem of donor organ shortage, the mechanisms of IRI are not well understood and new treatment and prevention strategies are needed.

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  1. Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/

    Iain Dickson

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  1. Iain Dickson
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Correspondence to Iain Dickson.

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Dickson, I. Improving hepatic ischaemia–reperfusion injury outcomes. Nat Rev Gastroenterol Hepatol 16, 583 (2019). https://doi.org/10.1038/s41575-019-0194-y

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