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T CELLS

Connecting angiogenesis and autoimmunity

Nature Reviews Immunology volume 19, pages 596–597 (2019)Cite this article

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T cell infiltration and angiogenesis occur concurrently during inflammation, such that newly recruited T cells in the perivascular area of chronically inflamed tissues are exposed to various angiogenic factors. Yoo et al. show that one such angiogenic factor — placental growth factor (PLGF) — not only is produced by T helper 17 (TH17) cells but also induces their differentiation, which suggests reciprocal links between angiogenesis and TH17 cell-mediated autoimmune disease.

Next, Yoo et al. investigated whether PLGF also has autocrine or paracrine effects on the T cells themselves. Splenocytes from Plgf-knockout mice produced significantly less IL-17 after stimulation than wild-type splenocytes, which suggests that PLGF regulates TH17 cell development. In keeping with this, addition of exogenous PLGF to CD4+ T cells increased their production of IL-17, and Plgf-transgenic TH17 cells produced more IL-17 and GM-CSF than wild-type TH17 cells, which is indicative of a more ‘pathogenic’ phenotype.

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  1. Nature Reviews Immunology http://www.nature.com/nri/

    Kirsty Minton

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  1. Kirsty Minton
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Correspondence to Kirsty Minton.

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Minton, K. Connecting angiogenesis and autoimmunity. Nat Rev Immunol 19, 596–597 (2019). https://doi.org/10.1038/s41577-019-0217-5

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