Fig. 2: Pathway contributing to COVID-19-associated coagulopathy. | Nature Reviews Immunology

Fig. 2: Pathway contributing to COVID-19-associated coagulopathy.

From: Understanding COVID-19-associated coagulopathy

Fig. 2: Pathway contributing to COVID-19-associated coagulopathy.

COVID-19-associated coagulopathy (CAC) likely involves the dysregulation of numerous pathways that, in ways that are not currently well understood, culminate in endothelial damage, thrombosis and multi-organ failure. ACE2, angiotensin-converting enzyme 2; autoantibodies, anti-phospholipid-targeting autoantibodies; IFITM3, interferon-induced transmembrane protein 3; NET, neutrophil extracellular trap; PAI-1, plasminogen activator inhibitor 1; ROS, reactive oxygen species; vWF, von Willebrand factor. Adapted with permission from ref.35, Elsevier.

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