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The broad spectrum of pathogenic autoreactivity

Nature Reviews Immunology volume 23, pages 69–70 (2023)Cite this article

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Self-reactive immune responses occur in autoimmune diseases and also in chronic inflammatory and metabolic diseases that are not generally considered as autoimmune diseases. How do the mechanisms of autoreactivity in the different settings overlap and how are they distinguished? Evidence indicates that while autoimmune diseases rely on both a supportive genetic background and a cooperative environment, chronic inflammatory and metabolic diseases strongly hinge on a conducive milieu for the activation of pathogenic autoreactive cells even in the absence of facilitating polygenic factors.

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Authors and Affiliations

  1. Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA

    Laura Santambrogio

  2. Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

    Laura Santambrogio

  3. Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA

    Laura Santambrogio

  4. Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA

    Philippa Marrack

Authors
  1. Laura Santambrogio
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  2. Philippa Marrack
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Correspondence to Laura Santambrogio.

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Santambrogio, L., Marrack, P. The broad spectrum of pathogenic autoreactivity. Nat Rev Immunol 23, 69–70 (2023). https://doi.org/10.1038/s41577-022-00812-2

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