This Genome Watch explores how a new antisense oligomer-based approach enables functional genomics of genetically intractable bacteriophages, revealing essential genes and infection mechanisms without requiring genetic modification.
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Neri, U. Licence to knockdown — the phage gene silencer. Nat Rev Microbiol 23, 756 (2025). https://doi.org/10.1038/s41579-025-01253-z
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DOI: https://doi.org/10.1038/s41579-025-01253-z