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HYPERTENSION

FGF21 ACEs hypertension

Nature Reviews Nephrology volume 14, page 413 (2018)Cite this article

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First, the researchers assessed the levels of FGF21 in mice following hypertension induced by angiotensin II (ANGII) infusion. In wild-type mice, ANGII infusion increased serum FGF21 levels and FGF21 mRNA levels in the liver, but not in adipose tissue. The production of FGF21 by the liver required peroxisome proliferator-activated receptor-α (PPARα), which is a key regulator of the metabolic response to fasting or starvation.

Next, the researchers observed that ANGII-induced hypertension and the associated vascular damage observed in wild-type mice were exacerbated in Fgf21–/– mice. Furthermore, in ex vivo arteries, ANGII-induced vascular dysfunction, upregulation of oxidative stress markers and production of reactive oxygen species (ROS) were greater in Fgf21–/– mice than in wild-type mice. Conversely, overexpression of FGF21 in wild-type mice suppressed all of these ANGII-induced effects. Thus, FGF21 protects mice against the effects of ANGII-induced hypertension.

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  1. Nature Reviews Nephrology http://www.nature.com/nrneph

    Grant Otto

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  1. Grant Otto
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Correspondence to Grant Otto.

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Otto, G. FGF21 ACEs hypertension. Nat Rev Nephrol 14, 413 (2018). https://doi.org/10.1038/s41581-018-0020-8

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