Transdermal detection of fluorescent markers has potential to provide point-of-care measurement of glomerular filtration rate. However, validation of proposed approaches and confirmation of their clinical utility should be required ahead of their adoption in the clinic.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Delanaye, P. et al. Diagnostic standard: assessing glomerular filtration rate. Nephrol. Dial. Transplant. 39, 1088–1096 (2024).
National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am. J. Kidney Dis. 39 (Suppl. 1), S1–S266 (2002).
Delanaye, P. & Mariat, C. The applicability of eGFR equations to different populations. Nat. Rev. Nephrol. 9, 513–522 (2013).
Ebert, N. et al. Assessment of kidney function: clinical indications for measured GFR. Clin. Kidney J. 14, 1861–1870 (2021).
Tuttle, M. & Levey, A. S. Relmapirazin, a new exogenous filtration marker, and more widespread use of measured GFR. Kidney Int. 106, 562–565 (2024).
Ebert, N. et al. Iohexol plasma clearance measurement protocol standardization for adults: a consensus paper of the European Kidney Function Consortium. Kidney Int. 106, 583–596 (2024).
Dorshow, R. B., Debreczeny, M. P., Goldstein, S. L. & Shieh, J. J. Clinical validation of the novel fluorescent glomerular filtration rate tracer agent relmapirazin (MB-102). Kidney Int. 106, 679–687 (2024).
Dorshow, R. B., Debreczeny, M. P. & Goldstein, S. L. Glomerular filtration rate measurement utilizing transdermal detection methodology. J. Am. Soc. Nephrol. https://doi.org/10.1681/ASN.0000000639 (2025).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
P.D. is a consultant for Nephrolyx. R.J.G. declares no competing interests.
Rights and permissions
About this article
Cite this article
Delanaye, P., Glassock, R.J. A difficult path to point-of-care measurement of glomerular filtration rate. Nat Rev Nephrol 21, 285–286 (2025). https://doi.org/10.1038/s41581-025-00947-0
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s41581-025-00947-0