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Push the bouton

Nature Reviews Neuroscience volume 23, page 69 (2022)Cite this article

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As spines and presynaptic boutons are closely connected, increased spine size creates mechanical pressure on the presynaptic bouton. Ucar et al. transiently pushed presynaptic boutons in rat brain slices with a glass pipette and found that this increased both glutamate release and SNARE complex assembly. Glutamate release was SNARE-dependent but calcium-independent. Glutamate uncaging increased glutamate release only when the adjacent spine extended and pushed the presynaptic boutons, revealing a mechanical mechanism that regulates glutamate release.

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  1. Nature Reviews Neuroscience http://www.nature.com/nrn/

    Sian Lewis

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  1. Sian Lewis
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Correspondence to Sian Lewis.

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Lewis, S. Push the bouton. Nat Rev Neurosci 23, 69 (2022). https://doi.org/10.1038/s41583-021-00552-7

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