Despite advances in HIV-1 treatment, half of all people living with HIV-1 experience HIV-associated neurocognitive disorders (HAND). Most of our understanding of HAND neuropathogenesis comes from studies of individuals with HIV-1 subtype B, which is responsible for a small proportion of global HIV-1 infections. By contrast, HIV-1 subtype C, which predominates in sub-Saharan Africa, affects many more people but remains poorly characterized, limiting our understanding of HAND at a global level.
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Los Alamos HIV Sequence Database: https://www.hiv.lanl.gov/content/sequence/HIV/mainpage.html
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Williams, M.E., Thela, L., Wood, C. et al. HIV-1 subtype diversity in the pathogenesis of neuroHIV. Nat. Rev. Neurosci. 27, 81–82 (2026). https://doi.org/10.1038/s41583-025-01015-z
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DOI: https://doi.org/10.1038/s41583-025-01015-z
