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SPONDYLOARTHRITIS

Understanding immunopathology of sacroiliitis

Nature Reviews Rheumatology volume 14, page 442 (2018)Cite this article

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Few studies have investigated the pathogenesis of sacroiliitis in axial spondyloarthritis (axSpA) and it is not well understood. Clinical, laboratory and imaging data were collected from 193 patients with axSpa at baseline and during follow-up. The most common feature in early sacroiliitis was subchondral pannus formation. Pannus invasion was found to be central to pathological degeneration of the cartilage. The researchers concluded that cartilage pannus invasion or endochondral ossification at baseline can predict radiological structural damage during follow-up.

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References

Original article

  • Wang, D. M. et al. Pannus inflammation in sacroiliitis following immune pathological injury and radiological structural damage: a study of 193 patients with spondyloarthritis. Arthritis Res. Ther. 20, 120 (2018)

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  1. Nature Reviews Rheumatology http://www.nature.com/nrrheum/

    Isobel Leake

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  1. Isobel Leake
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Correspondence to Isobel Leake.

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Leake, I. Understanding immunopathology of sacroiliitis. Nat Rev Rheumatol 14, 442 (2018). https://doi.org/10.1038/s41584-018-0052-2

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  • DOI: https://doi.org/10.1038/s41584-018-0052-2

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