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Choline uptake is vital for IL-1β-driven inflammation

Nature Reviews Rheumatology volume 15, page 320 (2019)Cite this article

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Inhibition of choline uptake and phosphorylation prevents production of IL-1β and IL-18 by activated macrophages, according to the results of a study published in Cell Metabolism.

“Our experimental approach [was] based on standard CTL1 knockdown experiments that we complemented by the use of choline-free medium and choline kinase inhibitors,” says Michael Karin, corresponding author.

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References

Original article

  • Sanchez-Lopez, E. et al. Choline uptake and metabolism modulate macrophage IL-1β and IL-18 production. Cell Metab. 29, 1–13 (2019)

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  1. Nature Reviews Rheumatology http://www.nature.com/nrrheum/

    Isobel Leake

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  1. Isobel Leake
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Correspondence to Isobel Leake.

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Leake, I. Choline uptake is vital for IL-1β-driven inflammation. Nat Rev Rheumatol 15, 320 (2019). https://doi.org/10.1038/s41584-019-0228-4

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  • DOI: https://doi.org/10.1038/s41584-019-0228-4

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