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GOUT

Genetic loci associated with progression to gout

Nature Reviews Rheumatology volume 15, page 512 (2019)Cite this article

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Researchers have identified two genetic loci (in CNTN5 and MIR302F) and one potential locus (in ZNF724) associated with progression from hyperuricaemia to gout. The first-of-its-kind genome-wide association study (GWAS) compared patients with gout to individuals with asymptomatic hyperuricaemia, rather than patients with gout to normouricaemic individuals (as has been done in previous GWAS), to identify loci that influence the transition from hyperuricaemia to gout. Comparisons with results from previous GWAS suggested the existence of distinct mechanisms during the normouricaemia-to-hyperuricaemia and hyperuricaemia-to-gout transitions.

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  1. Nature Reviews Rheumatology http://www.nature.com/nrrheum/

    Jessica McHugh

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  1. Jessica McHugh
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Correspondence to Jessica McHugh.

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McHugh, J. Genetic loci associated with progression to gout. Nat Rev Rheumatol 15, 512 (2019). https://doi.org/10.1038/s41584-019-0282-y

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