Obesity promotes osteoarthritis (OA) through complex and incompletely understood biomechanical, metabolic and inflammatory factors. New data in mice add to this complexity by showing that eating a high-fat diet increases the risk of OA for two generations of offspring, raising questions about disease mechanisms and future treatment strategies.
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Acknowledgements
The work of T.M.G. is supported by a grant from the National Institutes of Health (NIH), National Institute on Aging (R01AG049058) and a Merit Award from the Department of Veterans Affairs (I01BX004666). T.M.G. is a member of the Reynolds Oklahoma Center on Aging and maintains an adjunct Associate Professor role in The University of Oklahoma Health Sciences Center, Department of Biochemistry and Molecular Biology and Department of Physiology. The work of J.E.F. is supported by grants from the NIH National Institute of Digestive and Kidney Diseases (R24 DK090964, NIH-R56DK114711 and NIH-1UG3OD023248).
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T.M.G. declares that he receives National Institutes of Health research support for obesity-related osteoarthritis research. J.E.F. declares that he is a consultant to the scientific advisory board of Janssen Pharmaceuticals.
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Griffin, T.M., Friedman, J.E. How can parental obesity promote OA across generations?. Nat Rev Rheumatol 16, 129–130 (2020). https://doi.org/10.1038/s41584-020-0369-5
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DOI: https://doi.org/10.1038/s41584-020-0369-5
