Fig. 1: Post-infection hyperinflammation encompasses a spectrum of phenotypes.
From: Kawasaki disease and MIS-C share a host immune response
Various infectious triggers prompt an invariant gene expression signature termed the viral pandemic (ViP) signature (yellow line). The intensity of the post-infectious immune response drives the clinical phenotype, which can range from mild hyperinflammation to macrophage activation syndrome (MAS) and cardiogenic shock. Expression of a subset of the ViP signature, termed severe ViP (sVIP) signature (red line), correlates with disease severity. Kawasaki disease and multisystem inflammatory syndrome in children (MIS-C) share a similar immunobiology and phenotype with overlapping features reflecting different parts of the disease spectrum.
