Structural modification of RNA by adenosine-to-inosine editing renders self-RNA invisible to RNA sensors of the innate immune system. Lack of RNA editing unleashes inflammatory responses that can lead to autoinflammation. A deeper understanding of the associated signalling pathways might reveal potential targets for drug discovery for autoinflammatory diseases.
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Acknowledgements
The authors are supported by grants from the Deutsche Forschungsgemeinschaft (CRC237 369799452/B21 to M.L.K., CRC237 369799452/J to C.W.).
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Wolf, C., Lee-Kirsch, M.A. Keeping immunostimulatory self-RNA under the rADAR. Nat Rev Rheumatol 18, 681–682 (2022). https://doi.org/10.1038/s41584-022-00859-4
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DOI: https://doi.org/10.1038/s41584-022-00859-4
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