The role of proteases in cartilage degradation and the development of osteoarthritis is undeniable. Despite over two decades of research on protease inhibitors, however, the transition from preclinical promise to clinical success remains elusive, underscoring the urgent need to critically appraise the challenges and limitations inherent in preclinical studies.
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Rai, M.F. Appraising the evolving landscape of protease inhibition in osteoarthritis. Nat Rev Rheumatol 21, 131–132 (2025). https://doi.org/10.1038/s41584-024-01198-2
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DOI: https://doi.org/10.1038/s41584-024-01198-2
