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BLADDER CANCER

ADXBLADDER test better than cytology for NMIBC follow-up monitoring

Nature Reviews Urology volume 17, page 486 (2020)Cite this article

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ADXBLADDER, a urine test that detects MCM5 (presence of which in urine sediment can indicate the presence of a bladder tumour), is superior to urine cytology for detecting recurrence of non-muscle-invasive bladder cancer (NMIBC). A multicentre prospective, blinded study collected urine from patients before cystoscopy and compared cytology and ADXBLADDER results with cystoscopy diagnosis. ADXBLADDER had a sensitivity of 51.9%, a specificity of 66.4% and a NPV of 92%, with a sensitivity of 44.1% and 58.8% for low-grade and high-grade recurrences, respectively. Cytology sensitivity was 16.7%, specificity was 98% and NPV was 90.7%, with a sensitivity of 17.6% for both low-grade and high-grade recurrences. Thus, detection of both low-grade and high-grade recurrences by ADXBLADDER is superior to that of urine cytology, and the test could provide a reliable alternative to urine cytology in NMIBC follow-up monitoring.

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  1. Nature Reviews Urology http://www.nature.com/nrurol/

    Annette Fenner

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  1. Annette Fenner
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Correspondence to Annette Fenner.

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Fenner, A. ADXBLADDER test better than cytology for NMIBC follow-up monitoring. Nat Rev Urol 17, 486 (2020). https://doi.org/10.1038/s41585-020-0368-y

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  • DOI: https://doi.org/10.1038/s41585-020-0368-y

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