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Male infertility

GSTA2 mitigates DEHP-induced reproductive toxic effects

Nature Reviews Urology volume 22, page 198 (2025)Cite this article

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The environmental pollutant bis(2-ethylhexyl) phthalate (DEHP) induces oxidative stress, leading to impaired sperm parameters and reproductive toxicity.

In a new study published in Molecular and Cellular Endocrinology, the role of glutathione S-transferase A2 (GSTA2) — a known detoxifying agent against environmental pollutants — was assessed in counteracting DEHP-induced reproductive damage.

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  1. Nature Reviews Urology http://www.nature.com/nrurol/

    Maria Chiara Masone

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  1. Maria Chiara Masone
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Correspondence to Maria Chiara Masone.

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Masone, M.C. GSTA2 mitigates DEHP-induced reproductive toxic effects. Nat Rev Urol 22, 198 (2025). https://doi.org/10.1038/s41585-025-01016-8

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  • DOI: https://doi.org/10.1038/s41585-025-01016-8

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