Results from the SWOG S1011 and LEA trials show that extended pelvic lymph node dissection during radical cystectomy for muscle-invasive bladder cancer offers no survival benefit. Novel perioperative systemic therapies could lead to true survival improvement for patients with muscle-invasive bladder cancer undergoing radical surgery and have the potential to implement bladder-preserving strategies.
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Gust, K.M., Shariat, S.F. Knockout of extended pelvic lymph node dissection during radical cystectomy. Nat Rev Urol 22, 795–796 (2025). https://doi.org/10.1038/s41585-025-01029-3
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DOI: https://doi.org/10.1038/s41585-025-01029-3
