Transrectal ultrasound-guided prostate biopsy is associated with limitations including high infection rates, sampling limitations and patient discomfort, which have led to the development of the transperineal approach. Randomized trials show that transperineal biopsy offers at least equivalent detection of clinically significant prostate cancer, providing robust evidence for a clinical practice change.
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Hennes, D., Al-Khanaty, A., Chen, D.C. et al. End of the TRUS era: transperineal biopsy takes the lead in prostate cancer detection. Nat Rev Urol (2025). https://doi.org/10.1038/s41585-025-01090-y
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DOI: https://doi.org/10.1038/s41585-025-01090-y
