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How urology can embrace the patient-centric precision focal therapy approach for localized prostate cancer

Focal therapy for localized prostate cancer offers organ-sparing oncological control with functional preservation for carefully selected men, but the uptake of this approach remains limited. Prioritizing principle-based evaluation, long-term registries and aligned reimbursement will facilitate the adoption of focal therapy into guideline-endorsed standard of care.

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Correspondence to Sudharshanan Balaji.

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Balaji, S., Lepor, H. & Polascik, T.J. How urology can embrace the patient-centric precision focal therapy approach for localized prostate cancer. Nat Rev Urol (2026). https://doi.org/10.1038/s41585-026-01136-9

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