Extended Data Fig. 5: Evolution of vertebrate-associated negative-sense RNA virus genomes.

Representative genomes from negative-sense RNA virus families/genera are shown. The regions that encode major functional proteins or protein domains are labelled on each of the genomes. Homologous regions within each family are connected with orange dotted lines. Schematic phylogenetic relationships are shown next to the genomes diagrams. Coverage plots are shown underneath novel genome structures. Reverse-complementary sequences are shown for negative-sense RNA viruses with complete termini. A Sanger sequencing chromatogram is shown at a GC-rich hairpin-forming region of the Wenling frogfish arenavirus 2 genome, in which the coverage drops substantially. Host associations are labelled to the right of tree using solid circles with different colours. Host associations and abbreviation of functional domains are described at the bottom of the figure.