Extended Data Fig. 8: Distribution of α-Syn pathology in injected KOM2 mice.
From: Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
Heat maps to semiquantitatively demonstrate the CNS distribution of α-Syn pathology in KOM2 mice unilaterally injected with GCI-α-Syn or LB-α-Syn into the thalamus. α-Syn pathologies were analysed and graded by immunohistochemistry with Syn506 at one month (n = 3), three months (n = 5) and six month (n = 5) post injection. Each panel represents a coronal plane (bregma −1.22, −2.18, −2.92, −3.52, −4.48 mm) for each treatment group. Because there is no α-Syn pathology in the contralateral side, only the ipsilateral side is shown.
