Extended Data Fig. 1: Sequence alignment of the voltage sensor of NavAb with those of human Nav1.4 homologous domain (D)II, Nav1.4 DIV, Cav1.1 DII and Cav1.1 DIV. | Nature

Extended Data Fig. 1: Sequence alignment of the voltage sensor of NavAb with those of human Nav1.4 homologous domain (D)II, Nav1.4 DIV, Cav1.1 DII and Cav1.1 DIV.

From: Structural basis for gating pore current in periodic paralysis

Extended Data Fig. 1

Coloured rectangles represent transmembrane helices. Black arrows indicate residues that form the guanidinium binding site, blue arrows indicate the hydrophobic constriction site and red arrows indicate the conserved intracellular negative cluster.

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