Extended Data Table 2 Statistical analysis of voltage sensor water occupancy from molecular simulations

From: Structural basis for gating pore current in periodic paralysis

  1. Results of two-way t-tests on differences in average water count in 1 Å segments of the voltage sensor axial coordinate comparing wild-type and R3G mutant simulations. In each segment, we compare the mean of 60 values (n = 60, obtained from pooling the mean water counts of the four voltage sensor proteins from each of 15 simulation repeats). The HCS region (−5 to 1 Å, bold) has the largest effect size, indicating a region of biological significance.
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