Extended Data Fig. 3: Known DNA repair genes are important for cisplatin resistance.
From: Mutant phenotypes for thousands of bacterial genes of unknown function
We compared the growth of a gene deletion strain and the wild-type bacterium under varying cisplatin concentrations. We show all replicate growth curves for each genotype. We believe the higher overall growth for some of the wild-type experiments (for example, top middle) is random. We observe this phenomenon consistently for some bacteria and we speculate that this is due to varying oxygen content across the microplate. a, E. coli radD (n = 6 independent experiments per strain). b, D. shibae Dshi_2244 (n = 3 independent experiments for wild-type and n = 6 independent experiments for the mutant). c, Phaeobacter inhibens PGA1_c08960 (n = 4 independent experiments for wild-type and n = 6 independent experiments for the mutant). Dshi_2244 and PGA1_c08960 are orthologues of MmcB (DUF1052) from C. crescentus24.
