Extended Data Fig. 7: 60S subunits components clash with immature h44.
From: Visualizing late states of human 40S ribosomal subunit maturation
Overview over clash sites of large subunit components with pre-40S particles. Left, initiation factor eIF5B, which is potentially involved in formation of the 80S-like ribosome complex, occupies a similar binding site as TSR1. Middle, ribosomal protein uL23 and helices H69 and H71 of 28S rRNA clash with h44 in its immature position. Right, finally helix H66 of 28S rRNA clashes with a RIOK1 helix. A model of an 80S ribosome with eIF5B (PDB code 4UJD) was aligned to pre-40S states, and the factors are shown as overlays together with one of the 40S precursors.
