Extended Data Fig. 6: Cryo-EM density of the GABA_A receptor in conformation A.

a–e, Cryo-EM density map of the GABA_A receptor conformation A for a representative of each subunit. f–h, Cryo-EM density segments of loop C in α1, β2 and γ2-subunits. i–k, Cryo-EM density segments of M2 helix in α1, β2 and γ2-subunits. l–n, Cryo-EM density maps of ligand binding sites: flumazenil (l), two GABA binding sites (m, n).