Extended Data Fig. 9: Synchronization of the adolescent cohort who underwent QuantiFERON conversion following Mtb acquisition

. To identify changes in peripheral NK cell frequencies after acquisition of Mtb infection by cell-mixture deconvolution analysis, the timescale of the gene expression dataset (GSE116014) was realigned according to the time of first infection diagnosis instead of study enrolment, allowing the identification of gene-expression profiles obtained before infection diagnosis. Each individual is represented by a horizontal bar. The length of the bar represents the number of days between study enrolment and diagnosis with Mtb infection. During follow-up, each individual transitioned from an uninfected state (blue) to infected state (brown), that is, underwent QFT conversion. The black circles represent time points for which gene-expression data were available. Pre-infection (Pre) data (180–360 days) were compared to data obtained at the time of infection diagnosis or the nearest time point after diagnosis (Post) (0–360 days).