Extended Data Fig. 4: Changes in frequencies of peripheral B cell subsets in LTBI, active TB and after treatment.
From: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes
Forest plots for estimated frequencies of B cell subsets: naive B cells, memory B cells and plasma cells. a, Comparison between the uninfected state (n = 189) and LTBI (n = 145). b, Comparison between LTBI (n = 409) and active TB (n = 543). c, Comparison between active TB (n = 76) and end-of-treatment (n = 97). Cohort GSE identifiers are listed on the left. In the plots, boxes represent the standardized mean difference in estimated cellular proportions in a cohort between two comparison groups. The size of the box is proportional to the sample size of a given cohort. Lines indicate the 95% confidence interval of the corresponding effect sizes. Diamonds indicate the summary effect size (Summary), obtained by integrating the effect sizes from individual cohorts. The width of the diamond corresponds to its 95% confidence interval. The P values and q values for the summary effect sizes are shown above each plot.
