Extended Data Fig. 5: Changes in frequencies of peripheral T cell subsets, monocytes and granulocytes in LTBI, active TB and after treatment.

Forest plots for estimated frequencies of CD4⁺ αβ T cells, CD8⁺ αβ T cells, monocytes and granulocytes. a, Comparison between the uninfected state (n = 189) and LTBI (n = 145). b, Comparison between LTBI (n = 409) and active TB (n = 543). c, Comparison between active TB (n = 76) and end-of-treatment (n = 97). Boxes represent the standardized mean difference in estimated cellular proportions in a cohort between two comparison groups. The size of the box is proportional to the sample size of a given cohort. Lines indicate the 95% confidence interval of the corresponding effect sizes. Diamonds indicate the summary effect size (Summary), obtained by integrating the effect sizes from individual cohorts. The width of the diamond corresponds to its 95% confidence interval. The P values and q values for the summary effect sizes are shown above each plot.