Extended Data Fig. 5: Construction of the phylogeny using different methods.
From: Population dynamics of normal human blood inferred from somatic mutations
a, The phylogeny of cells as presented in Figs. 2, 4, 6, but with the addition of P values next to every node, derived by bootstrapping the substitution matrix 1,000 times, building a tree using SCITE for each replicate, and counting the proportion of the bootstrapped trees that support each node. b–f, Phylogenies constructed using different datasets and methods. In each case the phylogeny was constructed using 100 bootstraps of the data, and the P value for each node shown underneath it. Branches are coloured by whether a branch ancestral to exactly the same descendants is also present in the SCITE tree, and are drawn with a thicker line if the branch is recovered in ≥70% of bootstrap replicates. b, Substitution and indel datasets combined, building the tree by maximum parsimony. c, Substitution, indel and neighbour-joining datasets combined, building the tree by neighbour joining. d, Substitutions, tree build by maximum parsimony. e, Indels, tree built by maximum parsimony. f, Short tandem repeats, tree built by neighbour joining.
