Extended Data Fig. 6: Relationship between cell types in the phylogeny.

a, The phylogeny showing different stem and progenitor cell types. b, The phylogeny is shown as in a, but with the labels underneath coloured according to which cell types are being compared. The first row of labels has stem cells from bone marrow in red, progenitor cells from bone marrow in grey and stem cells from peripheral blood in black. The second row of labels has stem cells in red and bone marrow progenitors in black. The third row of labels has MEPs in red, CMPs in black, GMPs in blue and stem cells in grey. c–e, Analysis of molecular variance is used to test for clustering on the phylogeny for stem cells derived from peripheral blood versus bone marrow cells (c), stem cells versus progenitors (d) and different progenitor types (e). In each panel, a histogram of the null distribution of the statistic used to detect clustering is shown. Distributions were obtained by randomly permuting which cells were assigned to which category. Comparisons are only between cell types not shown in grey in b. The observed value of the statistic is shown as a red vertical line.