Extended Data Fig. 5: Comparison of closely matched sites identified in silico and off-target cleavage sites identified by CIRCLE-seq. | Nature

Extended Data Fig. 5: Comparison of closely matched sites identified in silico and off-target cleavage sites identified by CIRCLE-seq.

From: In vivo CRISPR editing with no detectable genome-wide off-target mutations

Extended Data Fig. 5: Comparison of closely matched sites identified in silico and off-target cleavage sites identified by CIRCLE-seq.

Venn diagrams comparing off-target cleavage sites in mouse genomic DNA identified by CIRCLE-seq experiments with closely matched sites (up to six mismatches relative to the on-target site) in the mouse genome identified in silico by Cas-OFFinder are shown for the Cas9 gRNAs gP, gM and gMH.

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