Extended Data Fig. 8: METTL3 expression correlates with lung tumour stage and promotes tumorigenicity.

a, Staining image of control and different stages lung cancer samples (n = 75). Bottom panels show the enlarged sections of the top panels. Scale bar, 30 μM. b, Western-blotting analysis using indicated antibodies. One experiment was performed. c, d, Tumour images (c) and plot of tumour weight (d) at the end point of the xenograft experiment. Data are mean ± s.e.m. from five independent mice. P values from a two-sided t-test. e–h, Western blotting analysis using the indicated antibodies. For e, two independently were performed experiments with similar results. For f–h, one experiment was performed. i, Tumour images at the endpoint in the xenograft experiment. Scale bar, 20 mm. j, Overlapping of genes containing m⁶A identified in four samples from patients with lung cancer. k, Distribution of m⁶A sites.