Extended Data Fig. 9: Polysome conformation is affected by METTL3 and m6A modification in primary human lung tumours.
From: mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis
a, Electron-microscopy images of polyribosomes. Images were taken from the samples in Fig. 3e. Scale bar, 50 nm. Six independently performed experiments show similar results. b, Gene Ontology analysis. Common methylated genes refers to the methylated genes in all four patient samples. ‘Not methylated genes’ indicates genes that are not methylated in any of the four patient samples. Hypergeometric distribution (one-tail) with Bonferroni adjustment was used to determine enrichment statistical significance. c, Venn diagram showing m6A peak overlap between patient tumour samples and cells (H1299 and A549).
