Extended Data Fig. 5: The NUDT9-H domain.
From: Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium
a, Sequence alignment of zebrafish (Dr), starlet sea anemone (Nv) and human (Hs) TRPM2 NUDT9-H domains with human NUDT9 using Clustal Omega55. b, c, Superimposition of the zebrafish ADPR/Ca2+–TRPM2 NUDT9-H domain (red) with human NUDT9 (green, PDB ID: 1Q33). Cap and core regions are indicated. d, e, Superimposition of the NUDT9-H domains of the zebrafish ADPR/Ca2+–TRPM2 structure (red) and the EDTA–TRPM2 structure (blue).
