Extended Data Fig. 7: Secondary structure arrangement of DrTRPM2 and sequence alignment of TRPM family channels.
From: Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium
The secondary structure prediction of DrTRPM2 was performed using the JPred online server56. The sequences (TRPM2 from zebrafish; TRPM2, TRPM4, TRPM5 and TRPM8 from human; TRPM2 from starlet sea anemone) were aligned using Clustal Omega55. Residues that are involved in ADPR binding and calcium binding are marked with red and black triangles, respectively. The cap and core regions of the NUDT9-H domain are indicated.
