Extended Data Fig. 1: Manhattan plot and spatial mapping of the associations between grey matter volume and rs13107325 (SLC39A8).
From: Genome-wide association studies of brain imaging phenotypes in UK Biobank
a, The Manhattan plot relates to the original GWAS for the IDP of grey matter volume in the left ventral striatum. b, c, Spatial mapping of rs13107325 against voxelwise local grey matter volume (grey matter was averaged across all 1,181 subjects with one copy of the non-reference allele, and the average from all 7,215 subjects that had zero copies was subtracted from that, for display in colour here; the difference was thresholded at 0.015 (unitless relative measure of local grey matter volume)). The maps show that the effect of rs13107325 is found more generally bilaterally in the ventral caudate, putamen, ventral striatum, anterior cingulate cortex, and with a strong cerebellar contribution (lobules VI–X), particularly in the prefrontal-projecting Crus I/II, which are selectively expanded in humans.
