Extended Data Fig. 9: Characterization of CD4+ TEMRA and tumour Treg cells by STARTRAC analysis.
From: Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
a, Violin plots showing normalized expression of cytotoxic related molecules in 12 CD4+ (n = 4,902 cells) and 8 CD8+ (n = 3,628) T cell clusters. Colours denote mean values; width denotes cell densities. b, Venn diagram highlighting common clonotypes (ncell ≥ 2) shared between tumour Treg and other CD4+ T cell clusters. c, Developmental transition of tumour Treg cells, TH17 cells and TH1-like cells with other CD4+ cells quantified by pSTARTRAC-tran indices for each patient (n = 11). d, Representative example of a CRC tumour stained by IHC, with white arrow showing co-expression of CD3, FOXP3 and RORγ (n = 2 patients). Original magnification, ×20.
