Extended Data Fig. 5: Trophoblast analysis.
From: Single-cell reconstruction of the early maternal–fetal interface in humans
a, UMAP visualization of the integrated analysis of the trophoblast subpopulations that were used for pseudotime analysis, including the enriched EPCAM+ and HLA-G+ cells (see Methods). Cells that were excluded from the pseudotime analysis are coloured in grey (n = 5 placentas, n = 11 deciduas). b, UMAP visualization of the log-transformed, normalized expression of selected canonical trophoblast marker genes (n = 5 placentas). c, Visualization of log-transformed, normalized expression of HLA-G, MKI67 and LGALS13 across trophoblast differentiation. d, Heat map showing genes that are involved in the epithelial–mesenchymal transition, identified as varying significantly as EVT differentiate (q value < 0.1, likelihood ratio test, P values were adjusted for the false discovery rate).
