Extended Data Fig. 9: PMI levels vary in human tumours, but do not predict overall survival and the weight of mice is not affected by mannose treatment in models of colorectal cancer.
From: Mannose impairs tumour growth and enhances chemotherapy
a, Images of PMI expression for each TMA, representing one negative sample (left), one low expression (middle) and one high expression (right). One sample came from each of the ovarian, breast, prostate, colorectal or renal TMAs as indicated. b, c, Kaplan–Meier curves showing cancer-specific survival based on PMI levels in n = 698 patients with stage I–IV colorectal cancer (b) or n = 316 patients with primary operable breast cancer (c). d, Table showing the association of PMI and cancer-specific survival. Histoscores were split into high and low expression using the ROC curve analysis for each tumour type. log-rank analysis (two-sided) was used to compare PMI and cancer-specific survival using SPSS (version 22). e, Mean weight of 28 mice during treatment with AOM and DSS, with or without additional mannose treatment. f, Weight of aged VillincreERApcfl/+KrasG12D/+ mice during treatment with or without mannose. Data are mean of each group (n = 7 mice, −mannose; n = 8 mice, +mannose).
